Starting sometime in 2016, I started seeing a number of positive reports from a nootropic that goes by many names: Nutrobal, Ibutamoren, and most commonly, MK-677.
Bodybuilders in several online communities that I am a part of were claiming that it was helping them to build lean mass fast even though it was not a growth hormone.
Intrigued, I dove head first into the research and found limited clincal studies, but numerous anecdotes and firsthand experiences attesting to the effectiveness of MK-677 as a muscle builder.
In the article below, I’ll be sharing exactly what I learned about MK-677, including its effectiveness, its known side effects and expected results.
Technically speaking, MK 677 is a selective androgen receptor modulator (S.A.R.M). That’s a bit of a mouthful, I know.
What MK-677 does is increase levels of key hormones that are essential to muscle growth (most notably GH, or Growth Hormone) in the body without increasing cortisol levels.
Which is great, because increased cortisol has negative effects on the immune system, learning, and memory.
Before I get further into this article, I do need to provide a disclaimer:
I am NOT a doctor, just a bodybuilding and nootropic enthusiast. Take my advice with a grain of salt and do your own research.
Cool? OK, let’s keep going.
The reason you are probably reading this article right now is that you’ve heard of a number of benefits from MK-677. I know I did, and they weren’t just limited to building muscle.
What people were telling me was that MK-677 helps to:
• Build muscle: MK-677 is an anabolic substance after all.
• Reduce muscle wasting
• Increase bone density according to this study
• Improve sleep quality: According to this study, “The present findings suggest that MK-677 may simultaneously improve sleep quality and correct the relative hyposomatotropism of senescence”.
My first thought upon reading these studies was: “You are telling me that MK 677 supplementation improves bone strength, metabolism, and general health, and possibly improves the immune system to some extent?”
This is either the find of a lifetime or some serious snake oil.
But after months of research and self-experimentation, I consider this to be a relatively safe and highly effective substance when dosed correctly.
The difference between Nutrobal (MK 677) and steroids is that Nutrobol mimics growth hormones, but is not a hormone itself.
This is different from steroids like HGH (Human Growth Hormone), which of course is an actual hormone that people inject themselves with. Which brings me to another benefit of MK 677 over steroids (which I don’t use or recommend as a natty bodybuilder) in that it can be taken orally and is not injected.
People usually take MK-677 for a few reasons:
• To “get swole son!”
• To tighten loose skin
• To speed up the healing of ligaments and bones
• To lose weight.
Unsurprisingly, MK-677 is best for bodybuilders in a bulk cycle.
If you are a competitive athlete, you should know that this substance is 100% banned by virtually every global sporting competition as a prohibited anabolic agent. So don’t take it if this is you.
But if you are a bodybuilder looking to increase your lean muscle mass, improve energy levels, and have longer, better workouts, then consider MK-677.
MK-677 Nutrobal Mechanism of Action
There are very few clinical studies dedicated to the research and testing of this compound, but we’ll share all the information we rounded up on MK 677 so far.
The most well-understood aspect of this compound is its anabolic muscle-building properties. MK 677 promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1) (R, R). The main purpose is binding ghrelin to one of the GHSR (ghrelin receptor) in the brain, which is necessary for the stimulation of growth hormones release from the brain.
MK 677 works through the following mechanisms of action:
• Encouraging the release of Growth Hormone Releasing Hormone, widely known as GHRH
• By releasing GHRH exponentially it amplifies the signaling in the somatotrophs of the anterior pituitary gland
• This nootropic also reduces the release of somatostatin, which slows down or stops the growth hormone from being released
• Lastly, Mk-677 Ibutamoren works by preventing or stopping the signaling of the somatostatin receptor
Benefits: SARM MK-677 Results
• One study showed great potential for the healing process of a condition involving muscle wasting, a sustained increase in serum concentration of the Growth Hormone and IGF-1. These results were accomplished by giving one daily oral dose of 25mg to an average healthy young male for 7 days.
• Another trial test revealed that MK 677 is effective in fighting obesity. The results showed an increase in lean body mass while causing minimal side effects. Many people don’t know that fat tissue is located deep in the abdomen and around internal organs, where it cushions them and promotes function. Taking substances that eliminate body fat can sometimes eliminate this healthy layer of fat as well as excess body fat
• A lot of other drugs used for burning fat can cause excessive accumulation of visceral adipose tissue (VAT) which increases the risk of heart attack, stroke, and diabetes.
• Elderly patients with fractured hips have also tried this nootropic and Ibutamoren improved gait speed, muscle strength and reduces the number of falls.
The increase in lean body mass is presumably caused by an increase in calorie allocation into the muscle and appetite decrease, which is opposite to reduction of the direct fat storage.
Lab geeks also noticed an increase in bone mineral density. This is how MK 677 actually helps with injury recovery. Other long-term benefits include an increased immune system response and nitrogen retention, along with an increase in strength and improved sense of well being.
Another triumph of Ibutamoren over HGH is that the effects with a full potential kick in way sooner (you’d need to take HGH for at least 4 months to achieve the same result). Our suggestion based on the research we did is to take MK-677 on an empty stomach at night to avoid hunger pains the next day, plus, you’ll sleep way better. You also may notice a better water retention in your body and full pumped muscles. Your muscles will start to look like that when the body fat decreases in the abdomen.
How to take MK677?
Regular users suggest that you start with 12.5 mg a day for the first week. That’s only half of a regular dose and this allows new users to see how their body reacts to the substance. Some users report that numb hands are something that happens in beginning and that it’s completely normal.
When should you be taking it? If you swallow one during the day you might feel a little tired or maybe exhausted. Also, daytime consumption is linked with excessive hunger. . Combining it with caffeine can combat both of these symptoms. On the other hand, taking it at night solves everything.
MK-677 Ibutamoren Side Effects
The truth is that the most common side effects of Mk 677 in many cases include slightly numb hands and increased appetite. That’s not much to worry about. You get numb hands when you go to an inhalation, or in the morning if you’ve slept on your arms wrong.
It’s important to note that there was a test trial that revealed several things about this nootropic. One study was canceled due to serious adverse events. However, the experiment was done on elderly patients who had an extensive history of medical illness, and one of them had a hip fracture before and ibutamoren raised his blood pressure, blood glucose, and HbA1c. In the same series of studies, other subjects had congestive heart failure. The patients undergoing these tests were over 80 and had a history of heart conditions.
This suggests that MK-677 can interact with some diseases and conditions, but we’re not sure which ones specifically. Be careful if you have any preexisting medical conditions.
The conclusive evidence so far suggests that people who suffer from cancer or diabetes should also avoid taking MK 677. Both IGF-1 and growth hormone may speed up the spreading of the cancer cells, and even those who don’t suffer from diabetes should check blood sugar levels regularly while taking ibutamoren.
The huge benefit of MK 677 is a small chance for any side effects, and if they occur they’re very little. If you’re wondering what causes them, our best guess is on unnecessary high doses. That means that getting rid of side effects is easy – lower the dose you’re taking.